This is the story of unbreakable bondage of friendship between three friends. Inspite of irritants cropping up same lines, their friendship remained blossoming.
Sandeep (JEETENDRA) is the son of a rich landlord Devendra Pratap Singh (PRAN). Prakash (RISHI KAPOOR) is the son of Devendra Pratap's friend and after the demise of his parents he was brought up in the house of Devendra Pratap from his child hood. Ranjit (RAJNI KANT) is the son of a ruthless, unscrupulous Drug rackets. His father abondons him, in when he was a small boy, because he was instrumental in getting his father arrested for trafficking in drugs. And thus the three friends grow up under the same roof. Sandeep becomes a famous doctor, Ranjit becomes an honest and upright police officer and Prakash becomes a crafty lawyer.
The three join hands and start demolishing the drug empire of Daga. Irritated by the constant onslaught on his business, Daga gets the wife of Ranjit, Lata (Poonam Dhillon) raped and takes out the video cassette of the rape. Sandeep reaches the spot and thrashes the culprit and saves Lata from commiting suicide, taking a promise from her to keep that horrible incident a secret from every one. Daga comes and kills his henchman. Sandeep is charged for the murder of Daga's henchman (DARA) Ranjit pursues the prosecution in a dutiful manner but Prakash manages to extricate Sandeep from the murder charge by producing the fictitious wife Rekha (BHANU PRIYA). Sandeep had saved the honour of Rekha earlier. The fictitious wife later becomes the real wife of Sandeep. Prakash gets hooked to Shanti (KIMI KATKAR). Shanti's brother was murdered by Daga. She became a tramp thereafter.
Things hot up between Daga and the three friends a big consignment of drugs is to be smuggled out India Daga's Syndicate friends Nishan (KADER KHAN) and Kaman (SHAKTI KAPOOR) come to India to supervise. The smooth transhipment of the drugs. Sandeep's wife is kidnaped by Daga. Ranjits wife, who is in an advanced stage of pregnancy and Shanti are kidnapped by Nishan and Kaman, because the consignment of drugs fall into hands of the police.
Whether the villain group is able to redeem the lost drug? What happened to pregnant wife of Sandeep? All this can be seen in a thrilling climax of DOSTI DUSHMANI.
(From the official press booklet)